A method and apparatus for applying a musical feedback signal to the human brain, or any other brain, to induce controllable psychological and physiological responses. A signal representing the ongoing electroencephalographic (EEG) signal of a brain preferably is obtained from the electrode location on the scalp known as CZ or P3 in clinical notation. A signal processor converts the ongoing EEG into electrical signals which are converted into music by synthesizers. The music is acoustically fed back to the brain after a time delay calculated to shift the phase of the feedback in order to reinforce specific or desired ongoing EEG activity from the scalp position of interest. The music is comprised of at least one voice that follows the moment-by-moment contour of the EEG in real time to reinforce the desired EEG activity. The music drives the brain into resonance with the music to provide a closed loop or physiological feedback effect. Preferably, the musical feedback comprises additional voices that embody psychoacoustic principles as well as provide the content and direction normally supplied by the therapist in conventional biofeedback. The invention contemplates numerous applications for the results obtained.